Pathogenic mechanism of second hand smoke induced inflammation and COPD

Pathogenic mechanism of second hand smoke induced inflammation and COPD

Second hand smoke (SHS) introduces thousands of toxic chemicals into the lung, including carcinogens and oxidants, which cause direct airway epithelium tissue destruction. It can also illicit indirect damage through its effect on signaling pathways related to tissue cell repair and by the abnormal induction of inflammation into the lung. After repeated exposure to SHS, these symptoms can lead t...

Second hand smoke and COPD: lessons from animal studies

1 Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA 2 Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland 3 Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, School of Medicine, University of Colorado, Denver, CO, USA *Corresponden...

Second hand smoke and COPD: lessons from animal studies

Exposure to second hand smoke is a major cause of chronic obstructive pulmonary disease (COPD) in the non-smoker. In this review we explore the use of animal smoke exposure models and their insight into disease pathogenesis. The methods of smoke exposure, including exposure delivery systems, are described. Key findings from the acute and chronic smoke exposure models are outlined, including des...

Second - hand Smoke and Cancer

The Effects of Second-hand Smoke Exposure on Breast Milk Cotinine and Infant Urinary Cotinine

Background & Aims: Exposure to cigarette smoke affects the health of mothers and infants. The aim of this study was to examine the effects of second-hand smoke exposure on breast milk and infant urinary cotinine during breastfeeding. Methods: This cohort study was conducted on 45 breastfeeding mothers and infants exposed to second-hand cigarette smoke (exposed group), and 40 breastfeeding mothe...